Caruthersville is a city in and the county seat of Pemiscot County, Missouri, United States, located along the Mississippi River in the Bootheel region of the state's far southeast. The population was 6,168, according to the 2010 Census.
Caruthersville is located at 36°11′5″N 89°39′41″W (36.184723, -89.661404). According to the United States Census Bureau, the city has a total area of 5.24 square miles (13.57 km²), of which, 5.16 square miles (13.36 km²) of it is land and 0.08 square miles (0.21 km²) is water. The city is located in the state's Bootheel along the western bank of the Mississippi River and within the seismically active New Madrid Seismic Zone. The Caruthersville Bridge is the only bridge crossing the river between Cairo, Illinois and Memphis, Tennessee.
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